Efficiency and safety of Vortioxetine in the treatment of depressive disorders in cardiac patients

Importance of the problem . Diseases cardiovascular system are in first place among causes death and disability most industrialized countries, which is undoubtedly an urgent medical social significant economic damage. The prevalence depressive disorders modern society, according to WHO estimates, quite high, methods for their correction patients with various somatic diseases have been subject study by specialists around world many decades. comorbidity cardiac pathology beyond doubt, bidirectional relationship these significantly aggravates condition patients, worsens quality life reduces adherence treatment. important conditions use antidepressants cardiology practice good tolerability, absence toxic effect, minimal interaction other drugs, relative safety case overdose. Vortioxetine, being a multimodal antidepressant, demonstrates not only sufficiently high antidepressant anti-anxiety activity, but also has procognitive as well side effects undesirable cross-interactions confirmed international randomized placebo-controlled trials. aim this work was evaluate efficacy Vortioxetine treatment concomitant coronary heart disease (CHD), angina pectoris 2-3 functional class (FC) (I 20.8 ICD-10), receiving complex therapy main (cardiological) at inpatient outpatient stages therapy. Materials included diagnosis artery disease, FC 2-3, hypertension aged 45 66 years (mean age 57.1±1.1 years), underlying dose 10-15 mg/day. within 8 weeks. Anxiety manifestations were assessed on HADS scale, level cognitive impairment PDQ questionnaire, functioning SF-36 general clinical impression CGI-C indicators upon admission hospital, after 4 weeks hospitalization. another discharge during period observation. result combined disorder (basic CVD Vortioxetine) improvement (decrease rate, blood pressure, frequency anginal pain, increase exercise tolerance), relief manifestations, contributed cardiological implementation recommendations, and, turn, led decrease end points—mortality, hospitalization rates, progression chronic failure disability. Conclusions Appointment moderate severity effective terms painful CVS, leads reduction anxiety-depressive functioning. tolerability drug makes it possible recommend hospital setting practice.